I have an acquaintence here in Portland who claims knowledge of “addictionology”. When I have mentioned that marijuana use causes dependence in a few, not addiction, he’s quick to correct me by saying that marijuana use causes the release of dopamine in the brain, just like any other addictive drug, and that is how we can consider marijuana to be physically addictive. I’ve always believed that correction to be faulty, but lacked the knowledge of brain functioning to offer a strong rebuttal.
Now it looks like I have a new study to back me up:
Background: Cannabis use in early adolescence may be a risk factor for development of schizophrenia. In animals, Delta9-tetrahydrocannabinol (THC) increases the rate of dopamine neuronal firing and release in the striatum. Thus cannabis use may increase dopamine release in the human striatum leading to vulnerability to psychosis
Aims: To investigate whether THC, the main psychoactive component of cannabis, can produce dopamine release in the human striatum.
Methods: 13 healthy volunteers, with previous cannabis experience, underwent two [11C]-raclopride positron emission tomography (PET) scans to indirectly measure striatal dopamine levels following either 10mg THC or placebo.
Results: Although THC markedly increased psychosis-like symptoms on the Psychotomimetic States Inventory (PSI), there was no significant effect of THC on [11C]-raclopride binding
Conclusion: In the largest study of its kind so far, we have shown that recreational cannabis users do not release significant amounts of dopamine from an oral THC dose equivalent to a standard cannabis cigarette. This result challenges current models of striatal dopamine release as the mechanism mediating cannabis as risk factor for schizophrenia.
Was it a intentional unintentional joke, “Conclusion: In the largest study of its kind so far…” Well its not really joke.
[...] Re: is there anyway to replenish dopamine Read this Study: Cannabis use does not increase dopamine release | The NORML Stash Blog [...]
WHAT. Why can’t I be so lucky as to be a test subject in a marijuana study?!
[...] inhibiting natural dopamine? THCs main mechanism of action has nothing to do with dopamine Study: Cannabis use does not increase dopamine release | The NORML Stash Blog Opiates actually do act on dopamine, which is an effect of their binding to proteins on opioid [...]
you’re a smart man.
Thats why they call it……dopamine.
Ha. Ha. Ha. Take that Anslinger. (did I spell his name right, who cares ?)
lol Your friend needs to catch up Russ!
Jon Gettman was publishing papers on this back in ’95. http://tr.im/pvxO
well duh!!!! lol like russ i never knew for sure but i figure that anything that slanders the name of cannabis is probably bullshit EXCEPT cough, munchies and possible laziness lol. because like the majority of you ive been smoking for a while and know and met MANY smokers and the last i checked were not all schitzi loonies who are dropping dead left and right from the supposed lung cancer that plagues cannabis users to losing our balls and heads from neck and testicular cancer to being so psycotic that we beat and murder people..wait a minute i think someone might have misplaced the original studies on cannabis and alchol cuz all these minus the lung cancer which then transfers to liver cancer are associated with heavy long-term alochol use! im in favor for whatever you put in your body but seriously it sometimes seems like they take all the bad shit you get from alochol and tobacco consumption and apply it to cannabis. i guess its all politics folks
and so 